What is Mefloquine Hydrochloride Tablets USP 250mg?

Mefloquine Hydrochloride Tablets USP 250mg is an antimalarial medication used for the treatment and prevention of malaria caused by Plasmodium falciparum. It is manufactured by Taj Pharma, a leading WHO-GMP certified pharmaceutical company in India.

Is Taj Pharma a certified Mefloquine tablets manufacturer?

Yes, Taj Pharma is a WHO-GMP certified Mefloquine tablets manufacturer in India with state-of-the-art manufacturing facilities and international quality standards. We hold multiple certifications including ISO 9001:2018, EU-GMP, and PICs.

How can I order Mefloquine tablets in bulk?

For bulk orders of Mefloquine tablets, you can contact our sales team through our website, call our 24/7 helpline at +91 84484 44095, or email us at info@tajpharma.com. We also support government tenders and international export orders.

What countries does Taj Pharma export Mefloquine tablets to?

Taj Pharma exports Mefloquine tablets to over 75 countries worldwide, including Africa, Southeast Asia, Middle East, and Latin America. We comply with international regulatory requirements for each target market.

What quality certifications does Taj Pharma have?

Taj Pharma holds WHO-GMP, ISO 9001:2018, EU-GMP, PICs, and SGS certifications. Our manufacturing facility is regularly inspected and approved by international regulatory authorities.

Safety Information - Mefloquine Tablets Manufacturer in India

Name: Mefloquine Hydrochloride Tablets USP 250mg
Brand: Mefloquin®
Availability: InStock

Important Safety Information

Comprehensive safety guidelines and precautions for Mefloquin® Tablets USP 250mg.

BOXED WARNING

PSYCHIATRIC SYMPTOMS: Mefloquine may cause neuropsychiatric adverse reactions that can persist after discontinuation. These include anxiety, depression, hallucinations, psychotic reactions, and suicidal ideation. Discontinue use and contact healthcare provider immediately if psychiatric symptoms occur.

Contraindications

Absolute Contraindications

Known hypersensitivity to mefloquine or related compounds
History of seizures or epilepsy
Current or recent history of depression, generalized anxiety disorder, psychosis, or other major psychiatric disorders
Recent use of halofantrine (within 2 weeks)

Relative Contraindications

Cardiac conduction abnormalities
Severe liver impairment
Pregnancy (especially first trimester)
Breastfeeding (consult healthcare provider)

Warnings & Precautions

Neurological Warnings

Dizziness, vertigo, and loss of balance
Headache and visual disturbances
Tinnitus and hearing impairment
Confusion and disorientation
May impair ability to drive or operate machinery

Cardiac Warnings

QT interval prolongation possible
Avoid in patients with cardiac arrhythmias
Caution with other QT-prolonging drugs
Monitor ECG in high-risk patients

Hepatic Warnings

Hepatotoxicity reported
Monitor liver function in prolonged use
Avoid in severe hepatic impairment
Dose adjustment may be needed

Ocular Warnings

Visual disturbances may occur
Blurred vision and difficulty focusing
Usually temporary but can be persistent
Avoid activities requiring clear vision

Drug Interactions

Drug Class	Interaction	Recommendation
Halofantrine	Increased cardiac toxicity	Contraindicated - avoid within 2 weeks
Quinidine, Quinine	Increased cardiac risk	Avoid concurrent use
Antiepileptics	Reduced mefloquine levels	Monitor efficacy
Live Vaccines	Reduced vaccine efficacy	Separate by 10 days
QT Prolonging Drugs	Increased arrhythmia risk	Avoid or monitor closely

Use in Pregnancy & Lactation

Pregnancy

First Trimester:

Contraindicated - risk of fetal harm outweighs benefits

Second/Third Trimester:

Use only if benefits outweigh risks - consult healthcare provider

Note: Women of childbearing potential should use effective contraception during and for 3 months after therapy.

Breastfeeding

Mefloquine is excreted in human milk. Caution should be exercised when administered to nursing mothers. The decision should be based on the importance of the drug to the mother.

Side Effects

Common Side Effects (>10%)

Nausea and vomiting
Diarrhea
Abdominal pain
Dizziness
Headache
Sleep disturbances
Unusual dreams

Serious Side Effects

Psychiatric: Depression, anxiety, psychosis, suicidal thoughts
Neurological: Seizures, confusion, ataxia, tremor
Cardiac: Arrhythmias, QT prolongation
Hepatic: Hepatitis, liver failure
Dermatological: Severe skin reactions, Stevens-Johnson syndrome

When to Seek Medical Help

Seek Immediate Medical Attention For:

Suicidal thoughts or self-harm
Severe depression or anxiety
Psychosis or hallucinations
Seizures or convulsions
Chest pain or irregular heartbeat
Severe allergic reaction (swelling, difficulty breathing)
Yellowing of skin or eyes (liver problems)

Contact Healthcare Provider For:

Persistent dizziness or balance problems
Visual disturbances
Mood changes or irritability
Sleep problems lasting more than a week
Unusual dreams or nightmares
Any concerning side effects

Emergency Contacts

Emergency

Call emergency services immediately

Poison Control

Contact your local poison control center

Medical Support

Contact Medical Team

Patient Safety Checklist

No history of psychiatric disorders
No history of seizures
Not pregnant or breastfeeding
No heart problems
Not taking contraindicated medications